Margaret Hilton, Ph.D.

About

Dr. Hilton completed her PhD at the University of Utah in 2017 with Matthew Sigman, working on the optimization and mechanisms of palladium-catalyzed reactions. She joined Scott Miller’s lab at Yale University for her postdoctoral studies, studying peptide catalysts for the late stage modification of natural products.   

 Recent Publications:

Hilton, M. J.; Brackett, C; Blagg, B.; Miller, S. J. “Catalysis-Enabled Access to Cryptic Geldanamycin Oxides” ACS Cent Sci. 2020, 6, 426–435.

Coelho, J. A. S.; Matsumoto, A.; Orlandi, M.; Hilton, M. J.; Sigman, M. S. Toste, F. D. “Enantioselective fluorination of homoallylic alcohols enabled by the tuning of non-covalent interactions” Chem. Sci. 2018, 9, 7153–7158.

Orlandi, M.; Hilton, M. J.; Yamamoto, E.; Toste, F. D.; Sigman, M. S. "Mechanistic Investigations of the Pd(0)-Catalyzed Enantioselective 1,1-Diarylation of Benzyl Acrylates" J. Am. Chem. Soc. 2017, 139, 12688.

Orlandi, M.; Coelho, J. A. S.; Hilton, M. J.; Toste, F. D.; Sigman, M. S. “Parametrization of Non-covalent Interactions for Transition State Interrogation Applied to Asymmetric Catalysis” J. Am. Chem. Soc. 2017, 139, 6803.

Neel, A.; Hilton, M. J.; Sigman, M. S.; Toste, F. D. “Exploiting Noncovalent π Interactions for Catalyst Design” Nature 2017, 543, 637.

Hilton, M. J.; Sigman, M. S.* "(S)-4-(tert-Butyl)-2-[4-(trifluoromethyl) pyridin-2-yl]-4,5-dihydrooxazole" Encyclopedia of Reagents for Organic Synthesis; John Wiley & Sons, Ltd: 2016.

Yamamoto, E.*; Hilton, M. J.*; Orlandi, M.; Saini, V.; Toste, F. D; Sigman, M. S. “Development and Analysis of a Pd(0)-Catalyzed Enantioselective 1,1-Diarylation of Acrylates Enabled by Chiral Anion Phase-Transfer” J. Am. Chem. Soc. 2016, 138, 15877. *contributed equally

Chen, Z.-M.; Hilton, M. J.; Sigman, M. S. “Palladium-Catalyzed Enantioselective Redox-Relay Heck Arylation of 1,1-Disubstituted Homoallylic Alcohols” J. Am. Chem. Soc. 2016, 138, 11461‒11464.

Hilton, M. J.; Cheng, B.; Buckley, B. R.; Xu, L.; Wiest, O.; Sigman, M. S.* “Relative reactivity of alkenyl alcohols in the palladium-catalyzed redox-relay Heck reaction,” Tetrahedron 2015, 71, 6513–6518.

Hilton, M. J.; Xu, L.-P.; Norrby, P.-O.; Wu, Y.-D.; Wiest, O.; Sigman, M. S. “Investigating the Nature of Palladium Chain-Walking in the Enantioselective Redox-Relay Heck Reaction of Alkenyl Alcohols,” J. Org. Chem. 2014, 79, 11841‒11850.

Xu, L.; Hilton, M. J.; Zhang, X.; Norrby, P.-O.; Wu, Y.-D.; Sigman, M.S.; Wiest, O. "Mechanism, Reactivity and Selectivity in Palladium-Catalyzed Redox-Relay Heck Arylations of Alkenyl Alcohols" J. Am. Chem. Soc. 2014, 136, 1960‒1967.