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569 Chemistry Research Laboratory Ph: (304) 293 – 3435×6217 Fax: (304) 293 – 4904 Email: jonathan.boyd@mail.wvu.edu |
Professional Preparation:
Ph.D., Environmental Toxicology
Texas Tech University
Lubbock, Texas (Aug 2004)
B.S., Biochemistry
University of Texas
Austin Texas (Dec 1998)
Research Interests:
Responses of living organisms to toxicants represent a set of complex interactions that build upon current state of health, previous history, and additional environmental influences which ultimately form a dynamic system of overall susceptibility. Susceptibility is not just a phenomenon of individual variation, but of populations that share common activities and exposures, which inevitably take the form of mixtures (multiple simultaneous or sequential). The reliance on whole animals in current mixtures toxicity testing approaches severely restricts the number of compounds and doses that one may experimentally use due to the associated time and costs, and typically results in experimentation with uncertain value. Rather, the ability to define toxicodynamic response pathways in vitro with a full dosing regime may identify possible interactions prior to animal testing and thereby limit the problem space which allows focused mixture experimentation with known value.
Recent Publications:
Krishnan K, Boyd J. Chapter 10: Toxicology of Chemical Mixtures. In General and Applied Toxicology, 3rd Edition. Ed. Ballantyne B. John Wiley & Sons Limited, Hoboken, NJ. (in press)
Krishnan K, Isukapalli S, Boyd J. Chapter 9:Evaluation of Toxicological Interactions for the Dose-Response Assessment of Chemical Mixtures. In General and Applied Toxicology, 3rd Edition. Ed. Ballantyne B. John Wiley & Sons Limited, Hoboken, NJ. (in press)
Patrone JB, Boggs NT, Theodore ML, Le HT, Boyd JW. “Exploring the boundaries of additivity: mixtures of NADH-quinone oxidoreductase (complex I) inhibitors. Toxicological Sciences (under review).
Coimbatore G, Cobb GP, Boyd JW, Marsland EJ, Presley SM. Sensing Biological and Chemical Threat Agents. In Advances in Biological and Chemical Terrorism Countermeasures. Eds. Smith PN, Austin GP, Presley SM, Kendall RJ. CRC Press Boca Raton, FL. pp 159-178. 2008.
Boyd JW, Eckman CK, Romero NA, Ramkumar SS, Cox SB, Cobb GP. “The use of a thermogravimetric analyzer for the generation of primary analytical vapor standards of organophosphate pesticides”. Analytica Chimica Acta, 558, 35-41. 2006.
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