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West Virginia University

Brian V. Popp

Assistant Professor


Address: 457 Chemistry Research Labs
Phone: 304-293-0773


Ph.D., University of Wisconsin, Madison J. Evans Attwell-Welch Postdoctoral Fellow, Rice University

Research Interests: Organometallic Chemistry and Catalysis, Chemical Kinetics and Mechanism, Computational Chemistry, Chemical Biology and Peptide Chemistry

Teaching Fields

Organic and Inorganic Chemistry

Courses Offered

Chem 521: Organometallic Chemistry
Chem 533: Advanced Spectroscopic Characterization of Organic Molecules
Chem 796D: Special Topics-Bioorganic Chemistry


1. “Sequence-Specific Inhibition of a Designed Metallopeptide Catalyst” Popp, B. V.; Chen, Z.; Ball, Z. T. Chem. Commun. 2012, 48, 7492-7494.

2. “Hybrid Organic-Inorganic Inhibitors of a PDZ Interaction that Regulates the Endocytic Fate of CFTR” Kundu, R.; Cushing, P. R.; Popp, B. V.; Zhao, Y.; Madden, D. R.; Ball, Z. T. _Angew. Chem. Int. Ed._ 2012, 51, 7217-7220.

3. “Reaction of O2 with [(-)-Sparteine]Pd(H)Cl: Evidence for an Intramolecular [H-L]+ “Reductive Elimination” Pathway” Decharin, N.; Popp, B. V.; Stahl, S. S. J. Am. Chem. Soc. 2011, 133, 13268-13271.

4. “Site-Specific Protein Modification with a Dirhodium-Metallopeptide Catalyst” Chen, Z; Popp, B. V.; Bovet, C. L.; Ball, Z. T. ACS Chem. Biol. 2011, 6, 920-925.

5. “Mechanistic Studies of Wacker-type Intramolecular Oxidative Amination of Alkenes Catalyzed by Pd(OAc)2/Pyridine” Ye, X.; Liu, G.; Popp, B. V.; Stahl, S. S. J. Org. Chem. 2011, 76, 1031-1044. * Recognized as a “Featured Article” by J. Org. Chem.

6. “Proximity-Driven Metallopeptide Catalysis: Remarkable Side-Chain Scope Enables Modification of the Fos bZip Domain” Popp, B. V.; Ball, Z. T. Chem. Sci. 2011, 2, 690-695. * Highlighted in Chemistry World

7. “O2 Insertion into a Palladium-Hydride Bond: Observation of Mechanistic Crossover between HX-Reductive-Elimination and Hydrogen-Atom-Abstraction Pathways” Konnick, M. M.; Decharin, N. D.; Popp, B. V.; Stahl, S. S. Chem. Sci. 2011, 2, 326-330.

8. “Electronic Structural Comparison of the Reactions of Dioxygen and Electron-Deficient Alkenes with Nitrogen-Chelated Palladium(0)” Popp, B. V.; Morales, C. M.; Landis, C. R.; Stahl, S. S. Inorg. Chem. 2010, 49, 8200-8207. * Recognized as the Cover Article by Inorg. Chem.

9. “Helix Induction by Dirhodium: Access to Biocompatible Metallopeptides with Defined Secondary Structure” Zaykov. A.; Popp, B. V.; Ball, Z. T. Chem. Eur. J. 2010, 16, 6651-6659.

10. “Structure-Selective Modification of Aromatic Side Chains with Dirhodium Metallopeptide Catalysts” Popp, B. V.; Ball, Z. T. J. Am. Chem. Soc. 2010, 132, 6660-6662. * Highlighted in Chemical Engineering Progress Magazine

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